Carboplatin and Pregnancy
In studies on carboplatin and pregnancy, birth defects and miscarriages occurred when the drug was given to pregnant animals. Because of this, the FDA has classified it as a pregnancy Category D medicine, meaning it is probably not safe for pregnant women. However, your healthcare provider may still prescribe this chemotherapy drug if the benefits outweigh the risks.
Can Pregnant Women Take Carboplatin?Carboplatin is generally considered unsafe for use during pregnancy. In animal studies that looked at the effects of this drug, carboplatin caused miscarriages and birth defects when given to pregnant animals.
What Is Pregnancy Category D?The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category D is given to medicines that have shown clear evidence of risk to the fetus in studies. This is a stronger warning than a pregnancy Category C classification.
However, a pregnancy Category D medicine may still be given to a pregnant woman if the healthcare provider believes that the benefits to the woman outweigh the possible risks to the unborn child.
Carboplatin was given a pregnancy Category D rating because of problems discovered during animal studies. When given to pregnant rats, it increased the risk of miscarriage and a variety of different birth defects.
There are only two reports of the use of carboplatin in human pregnancy. In both cases, the drug was used in the second or third trimester and did not appear to cause any problems for the fetus. No cases of carboplatin use during the first trimester (probably the riskiest trimester to use the drug) in humans have been reported.
Of note, there have been several cases of successful pregnancies (either occurring naturally or with donor eggs) in women who had undergone treatment with carboplatin.