Cisplatin Drug Interactions

Cisplatin Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when cisplatin is combined with any of the drugs listed above.
 
Aminoglycoside Antibiotics
Cisplatin and aminoglycoside antibiotics are known to cause hearing loss or kidney damage. Taking them together may increase the risk of these problems. However, in some situations, the benefits of using these medications may outweigh these possible risks.
 
Docetaxel
Combining docetaxel with cisplatin can increase the risk of dangerous side effects, particularly problems with bone marrow and blood cells. Talk to your healthcare provider about the risks and benefits of using these medications together. It is thought that giving the docetaxel first (and the cisplatin second) may help limit such problems.
 
Leflunomide
Combining leflunomide with cisplatin may increase the risk of dangerously low blood counts. Check with your healthcare provider before taking these medications together.
 
Live Vaccinations
Because chemotherapy drugs (including cisplatin) can suppress the immune system, it is generally best to avoid live vaccinations while undergoing chemotherapy treatment.
 
Loop Diuretics
Loop diuretics and cisplatin can both cause hearing loss or ringing in the ears (tinnitus). Taking them together may increase the risk of such problems.
 
Natalizumab
Combining cisplatin with natalizumab may increase the risk of serious infections. In general, this combination of medications should be avoided.
 
Paclitaxel
Combining paclitaxel with cisplatin can increase the risk of dangerous side effects, particularly problems with bone marrow and blood cells. Talk to your healthcare provider about the risks and benefits of using these medications together. It is thought that giving the paclitaxel first (and the cisplatin second) may help limit such problems.
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