Doxil Drug Interactions

Doxil Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Doxil is combined with any of the drugs listed above.
 
Cyclophosphamide (Cytoxan, Neosar)
Taking cyclophosphamide with Doxil may increase your risk of side effects. Be sure to talk to your healthcare provider about the risks and benefits of using these medications together.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
Combining cyclosporine with Doxil can increase the risk of dangerous side effects, including seizures and problems with bone marrow and blood cells. Talk to your healthcare provider about the risks and benefits of using these medications together.
 
Cytarabine (Cytosar-U)
There have been reports of dangerous side effects when cytarabine was used with Doxil. These included severe inflammation of the colon and bloody stools.
 
Live Vaccinations
Because chemotherapy (including Doxil) can suppress the immune system, it is generally best to avoid live vaccinations while receiving chemotherapy.
 
Paclitaxel (Onxol, Taxol)
Taking paclitaxel with Doxil can increase your risk of side effects. Talk to your healthcare provider about the benefits and risks of using these medications together.
 
Phenobarbital (Luminal)
Phenobarbital may decrease the level of Doxil in your blood, perhaps making it less effective. Your healthcare provider may need to adjust your Doxil dosage to prevent this drug interaction from occurring.
 
Phenytoin (Dilantin, Phenytek)
Doxil may decrease the level of phenytoin in your blood, perhaps making it less effective. Your healthcare provider may need to monitor your phenytoin levels and adjust your dosage as necessary.
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