Hexalen Drug Interactions

Hexalen Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Hexalen is combined with any of the drugs listed above.
 
Amphotericin B
Using amphotericin B in combination with chemotherapy medicines, including Hexalen, may increase the risk for potentially serious amphotericin B side effects, such as kidney damage, low blood pressure (hypotension), and lung problems. Your healthcare provider may choose to monitor you more closely if you take these medicines together. 
 
Biologic and Immunologic Medications
If you take certain biologic or immunologic medicines in combination with Hexalen, it may increase your risk for potentially serious side effects, such as infections and anemia. Hexalen should not be used in combination with some biologic or immunologic medicines, while other combinations will require close monitoring. Talk to your healthcare provider about this potential interaction if you are taking a biologic or immunologic medicine.
 
Cimetidine
Cimetidine may increase blood levels of Hexalen, potentially increasing the risk for Hexalen side effects. Talk to your healthcare provider before taking cimetidine during Hexalen therapy. There are similar medicines your healthcare provider may be able to recommend that are less likely to interact with Hexalen.
 
Clozapine
Taking clozapine and Hexalen together may cause extremely low white blood cell counts, which would increase your risk for life-threatening infections. Talk to your healthcare provider about this potential interaction if you take clozapine. You should not stop taking clozapine unless your healthcare provider specifically tells you to do so.
 
Echinacea       
Echinacea could potentially decrease the effectiveness of Hexalen. Do not take echinacea during Hexalen treatment without first speaking with your healthcare provider.
 
Live Vaccinations
Live vaccines contain live viruses or bacteria. It is generally recommended that people receiving chemotherapy not receive live vaccines. This is because chemotherapy medicines, including Hexalen, may increase your risk for infections, and you could become infected with the virus or bacteria used to make a live vaccine. Also, live vaccines may be less effective during chemotherapy treatment.
 
Talk to your healthcare provider before getting a vaccination while you are taking this drug.
 
Monoamine Oxidase Inhibitors (MAOIs)
Combining an MAOI with Hexalen may increase your risk for extremely low blood pressure, especially when getting up from a seated or lying position. This could cause you to become faint or fall down. If you take these medicines together, make sure you sit up or stand slowly, especially if you feel dizzy or faint.
 
Pyridoxine
In a clinical study, pyridoxine was shown to reduce the nervous system side effects associated with Hexalen. However, pyridoxine also reduced the effectiveness of Hexalen and, therefore, should probably not be used in combination with Hexalen.
 
Roflumilast
Combining roflumilast with Hexalen may further increase your risk for developing infections. Talk to your healthcare provider about this potential interaction before taking these medicines together.
 
Sipuleucel-T
Sipuleucel-T is thought to work by stimulating the body's immune system. Because Hexalen decreases the activity of the immune system, it could decrease the effectiveness of sipuleucel-T. Talk to your healthcare provider about this possible interaction before taking these medicines together.
 
Tricyclic Antidepressants (TCAs)
Combining a TCA with Hexalen may increase your risk for extremely low blood pressure, especially when getting up from a seated or lying position. This could cause you to become faint or fall down. If you take these medicines together, make sure you sit up or stand slowly, especially if you feel dizzy or faint.
 
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