Ovarian Cancer Home > Doxil and Pregnancy
Because Doxil (liposomal doxorubicin) caused problems in studies of pregnant animals, the FDA has listed it as a pregnancy Category D medication. In these studies, Doxil increased the risk of miscarriage and embryo death. If you are pregnant, discuss your chemotherapy options with your healthcare provider. He or she can provide information about the risks of using this product in your particular situation.
Can Pregnant Women Use Doxil?Doxil® (liposomal doxorubicin) is generally considered unsafe for use during pregnancy. In animal studies that looked at the effects of Doxil on pregnancy, the drug caused miscarriages and birth defects.
What Is Pregnancy Category D?
The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category D is given to medicines that have shown clear evidence of risk to the fetus in studies.
Pregnancy Category D is a stronger warning than a pregnancy Category C classification. However, a pregnancy Category D medicine may still be given to a pregnant woman if the healthcare provider believes that the benefits to the woman outweigh the possible risks to the unborn child.
Doxil was given a pregnancy Category D rating because of problems in animal studies. When given to pregnant rats and rabbits, it increased the risk of miscarriage and embryo death. Information from studies using the nonliposomal formulation of doxorubicin indicated that the drug may also increase the risk of birth defects.