Ovarian Cancer Home > Thiotepa

People who have ovarian cancer, bladder cancer, or various other types of cancer may benefit from treatment with thiotepa. This prescription drug is also used to reduce the excess fluid that can build up around certain body cavities due to cancer. It is given as an injection into a vein or directly into the body cavity once every one to four weeks.


What Is Thiotepa?

Thiotepa (Thioplex®) is a prescription medication approved for the treatment of a variety of types of cancer, such as bladder cancer, breast cancer, cancer of the ovaries, and lymphoma (cancer of the immune system). It is also used to control the abnormal accumulation of fluid in body cavities (known medically as effusion) that may result from certain cancers.
Thiotepa belongs to a group of chemotherapy medicines known as alkylating agents. It may also be referred to by the names triethylenethiophosphoramide, TSPA, or TESPA.
(Click What Is Thiotepa Used For? for more information on this topic, including possible off-label uses.)

Are There Side Effects?

Just like any chemotherapy medicine, thiotepa can cause side effects, some of which can be significant and potentially serious. Talk with your healthcare provider about ways to prevent or lessen reactions to this drug.
Possible side effects of thiotepa include but are not limited to:
  • A decrease in blood cell counts
  • Fatigue
  • Weakness
  • Loss of appetite
  • Nausea and vomiting.
(Click Thiotepa Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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