Drug Interactions With Melphalan

There have been reports of people developing severe kidney failure after receiving intravenous (IV) melphalan followed by cyclosporine. If you are taking cyclosporine, your healthcare provider should monitor your kidney function during melphalan treatment.
Melphalan may decrease the amount of digoxin absorbed from your gastrointestinal (GI) tract into your bloodstream. This interaction is more of a concern with digoxin tablets, and less of a concern with liquid forms of digoxin. If you are on digoxin therapy, your healthcare provider may need to adjust your digoxin dose, especially when you start melphalan, stop melphalan, or have a change in your melphalan dosage.
Echinacea could potentially decrease the effectiveness of melphalan. Do not take echinacea during melphalan treatment without first speaking with your healthcare provider.
Live Vaccinations
Live vaccines contain live viruses or bacteria. It is generally recommended that people receiving chemotherapy not receive live vaccines. This is because chemotherapy medicines, including melphalan, may increase your risk for infections, and you could become infected with the virus or bacteria used to make a live vaccine. Also, live vaccines may be less effective during chemotherapy treatment. Talk to your healthcare provider before getting a vaccination while you are taking this drug.
Combining roflumilast with melphalan may increase your risk for developing infections. Talk to your healthcare provider about this potential interaction before taking these medicines together.
Sipuleucel-T is thought to work by stimulating the body's immune system. Because melphalan decreases the activity of the immune system, it could decrease the effectiveness of sipuleucel-T. Talk to your healthcare provider about this possible interaction before using these medicines together.
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Melphalan Drug Information

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