Drug Interactions With Thiotepa

More Detail on Drug Interactions With Thiotepa

The following sections explain in detail the potentially negative interactions that can occur when thiotepa is combined with any of the drugs listed above.
 
Amphotericin B
Combining amphotericin B with chemotherapy medicines, including thiotepa, may increase the risk for amphotericin B side effects, such as kidney damage, low blood pressure (hypotension), and lung problems. Your healthcare provider may choose to monitor you more closely if you use these medicines together.
 
Bupropion
Thiotepa may increase blood levels of bupropion, potentially increasing the risk for bupropion side effects. Talk to your healthcare provider about this potential interaction if you take bupropion during thiotepa treatment.
 
Biologic and Immunologic Medications
Using thiotepa in combination with certain biologic and immunologic medications could increase your risk for potentially serious side effects, including infections and anemia. Thiotepa should not be used in combination with some of these medications, while other combinations require careful monitoring. Talk to your healthcare provider about this potential interaction if you are taking a biologic or immunologic drug during thiotepa treatment.
 
Clozapine
Using clozapine and thiotepa together may increase the risk for dangerously low white blood cells and potentially serious infections. Talk to your healthcare provider before using these medicines together. However, do not stop taking clozapine unless your healthcare provider specifically tells you to do so.
 
Cyclophosphamide
Thiotepa may increase blood levels of cyclophosphamide, increasing the risk for cyclophosphamide side effects. Talk to your healthcare provider about this potential interaction if you use these medications together.
 
Echinacea
Echinacea may decrease the effectiveness of thiotepa. Do not take echinacea during thiotepa treatment without first speaking with your healthcare provider.
 
Efavirenz
Thiotepa may increase blood levels of efavirenz, increasing the risk for efavirenz side effects. Talk to your healthcare provider about this potential interaction if you use these drugs together.
 
Irinotecan
Thiotepa may increase blood levels of irinotecan, increasing the risk for irinotecan side effects. Talk to your healthcare provider about this potential interaction if you take irinotecan during chemotherapy treatment.
 
Ketamine
Thiotepa may increase blood levels of ketamine. Ketamine is typically used as a general anesthetic (a medication that causes you to be unconscious) before certain medical procedures. Make sure your healthcare provider knows you are using thiotepa if you will be receiving ketamine during chemotherapy treatment.
 
Live Vaccinations
Live vaccines contain live viruses or bacteria. If you receive a live vaccine during thiotepa treatment, you could become infected with the virus or bacteria used to make the vaccine. Also, live vaccines may be less effective in people receiving thiotepa. You should not receive a live vaccine during chemotherapy treatment.
 
Methadone
Thiotepa may increase methadone blood levels, which could increase the risk for potentially serious methadone side effects. Talk to your healthcare provider about this potential interaction if you take methadone during chemotherapy treatment.
 
Other Chemotherapy Alkylating Agents
In general, combining chemotherapy medicines that work in the same way may increase the risk for developing side effects, such as bone marrow depression (low blood cell counts). The manufacturer of thiotepa recommends that such medicines not be used together.
 
If you have been treated with another alkylating agent prior to using thiotepa, your healthcare provider will need to make sure your blood cell counts have recovered before starting treatment. Likewise, if you will be receiving another alkylating agent after thiotepa, your blood cell counts should be near normal before starting treatment. 
 
Promethazine
Thiotepa may increase promethazine blood levels, increasing the risk for promethazine side effects. Talk to your healthcare provider about this potential interaction if you use these drugs together. Your healthcare provider may give you a lower promethazine dosage.
 
Propofol
Thiotepa may increase blood levels of propofol. Propofol is normally used to render people unconscious before certain medical procedures. Make sure your healthcare provider knows you are using thiotepa if you will be receiving propofol during chemotherapy treatment.
 
Roflumilast
Combining roflumilast with thiotepa may further increase your risk for developing infections. Talk to your healthcare provider about this potential interaction before using these medicines together.
 
Selegiline
Thiotepa may increase selegiline blood levels, increasing the risk for selegiline side effects. Talk to your healthcare provider about this potential interaction if you use these drugs together. Your healthcare provider may need to adjust your selegiline dosage.
 
Sipuleucel-T
Thiotepa may decrease the effectiveness of sipuleucel-T. This is because sipuleucel-T is thought to work by stimulating the body's immune system, while thiotepa decreases the activity of the immune system. Talk to your healthcare provider about this possible interaction before using these medicines together.
 
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Thiotepa Drug Information

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