The amount of thiotepa your healthcare provider prescribes will be based on how much you weigh, the type of cancer you have, and other factors. This drug is given as an injection into a vein or directly into the bladder or affected body cavity. Thiotepa dosing regimens will vary, but the drug can be given every one to four weeks.
The dose of thiotepa (Thioplex®) your healthcare provider recommends will vary, based on a number of factors, including:
- Your weight and possibly your height
- How the medication is being given
- The type of cancer you have
- How you respond to and tolerate it
- Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
The recommended thiotepa dose for intravenous (IV) injection (an injection into a vein) is usually 0.3 mg to 0.4 mg per kg body weight (0.14 mg to 0.18 mg per lb) every one to four weeks. The usual recommended dose for injection directly into a body cavity, such as the lining of the lungs, heart, or abdomen (stomach), is 0.6 mg to 0.8 mg per kg (0.27 mg to 0.36 mg per lb) every one to four weeks.
The recommended dosage of thiotepa for administration directly into the bladder for people with bladder cancer is 60 mg once a week for four weeks. The dose may be repeated for an additional four to eight weeks if needed. Giving the medication for longer than four weeks increases the risk for side effects.
In general, higher thiotepa doses are normally used initially. Because this drug decreases the number of blood cells in your body, your healthcare provider will use blood tests to check how much your blood cells have been affected by each dose. Your next dose will be adjusted based on the results of these blood tests.
It is important to keep in mind that the doses discussed here are general recommended amounts. However, the actual dose of thiotepa can vary considerably from person to person. For example, in some cases a healthcare provider may recommend an amount based on body surface area. Body surface area is normally calculated using your height and weight. Your healthcare provider will choose the best dosing regimen for you, based on your individual situation.