You should talk with your healthcare provider prior to receiving this medication if you have:
- Liver disease, such as hepatitis, cirrhosis, or liver failure
- Kidney disease, such as kidney failure (renal failure)
- Bone marrow depression (when the bone marrow does not make adequate amounts of blood cells) or bone marrow disease
- Any other allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant (see Thioplex and Pregnancy)
- Breastfeeding (see Thioplex and Breastfeeding).
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Thiotepa to learn more, including information on who should not use the drug.)
Thiotepa is part of a group of medications called alkylating agents. Alkylating agents are medications that transfer a piece of their structure, called an alkyl group, to DNA. This causes the strands of DNA to bond to each other and become linked (known as "cross-linking"). The linked strands are unable to uncoil and separate, which is necessary for the DNA to replicate.