Drug Interactions With Topotecan

Drug Interactions With Topotecan Explained

The following sections explain in detail the potentially negative interactions that can occur when topotecan is combined with any of the drugs listed above.
 
Filgrastim
Taking filgrastim and topotecan at the same time may prolong the low levels of neutrophils (neutropenia) that usually occur with topotecan treatment, increasing the risk for serious infections. If both of these medications are used, filgrastim should not be given until at least 24 hours after the last dose of topotecan in the cycle (for instance, on day six for a five-day topotecan cycle).
 
Live Vaccinations
Because chemotherapy (including topotecan) can suppress the immune system, it is generally best to avoid live vaccinations while receiving chemotherapy.
 
Pegfilgrastim
Taking pegfilgrastim and topotecan at the same time may prolong the low levels of neutrophils (neutropenia) that usually occur with topotecan treatment, increasing the risk for serious infections. If both of these medications are to be used, pegfilgrastim should not be given until at least 24 hours after the last dose of topotecan in the cycle (for instance, on day six for a five-day topotecan cycle).
 
P-Glycoprotein Inhibitors
Medications that inhibit a "transporter" known as P-glycoprotein (PGP) can cause the body to be exposed to significantly more topotecan than normal. This is likely to be a problem primarily for the oral (capsule) form of topotecan, rather than the intravenous (IV) form.
 
Platinum Analogues
Combining topotecan with platinum analogues can increase the risk of dangerous side effects, particularly problems with bone marrow and blood cells. Talk to your healthcare provider about the risks and benefits of using these medications together. It is thought that giving the topotecan first (and the platinum analogue second) may help limit such problems.
 
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Topotecan Chemotherapy Information

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