Topotecan Overdose

It is possible for a person to take too much topotecan (Hycamtin). The overdose effects caused by this chemotherapy medication can include a decreased ability of the bone marrow to produce blood cells. This dangerous complication can lead to anemia and an increased risk of serious infections. Treatment typically involves treating any symptoms that develop as a result of the overdose.

Can You Take Too Much Topotecan?

Topotecan (Hycamtin®) is a prescription chemotherapy medication that is given intravenously (by IV) or in capsule form (by mouth). As with most medications, it is possible to take too much topotecan. The specific effects of an overdose will likely vary, depending on a number of factors, including the topotecan dosage and whether it was taken with any other medications or substances.

Effects of a Topotecan Overdose

The most serious effect of an overdose can involve bone marrow depression, which is a decreased ability of the bone marrow to produce blood cells. This can result in anemia and other serious conditions (see Chemotherapy and Anemia).
Because your immune system depends on certain blood cells, an overdose of topotecan can increase the risk of serious infections (see Chemotherapy and Infections). You may also be at a higher risk for bleeding (see Blood Clotting Problems and Chemotherapy).

Treatment Options

There is no specific antidote for a topotecan overdose. Therefore, the treatment for this type of overdose mainly consists of treating any symptoms that occur. For instance, medications can be given to help stimulate the production of blood cells, and antibiotics may be given to people with very low white blood cells (as these people are at a high risk for dangerous infections).
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Topotecan Chemotherapy Information

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