What Is Topotecan Used For?

How Does It Work?

Topotecan is part of a group of medications called topoisomerase I inhibitors. Topoisomerase I is an enzyme that normally helps unwind DNA during the cell division process. The enzyme helps the process by creating temporary nicks in the DNA to help relieve strain. Topotecan interferes with this process, preventing the DNA from unwinding and causing excess DNA strain.

Is This Medication Safe for Children?

Topotecan is approved for adults only, as it has not been adequately studied in children. Talk with your child's healthcare provider about the benefits and risks of using topotecan in children.

Can You Use Topotecan Off-Label?

On occasion, your healthcare provider may recommend topotecan for something other than the uses discussed in this article. Such uses are known as "off-label" uses. Using topotecan to treat any other type of cancer would be considered an off-label use.
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Topotecan Chemotherapy Information

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